People from Monroe County, Georgia

Robert Lee "Chick" Willis (September 24, 1934 – December 7, 2013) was an American blues singer and guitarist, who performed and recorded from the 1950s to the 2000s.

Alfred Blalock (April 5, 1899 – September 15, 1964) was an American surgeon most noted for his work on the medical condition of shock as well as Tetralogy of Fallot— commonly known as Blue baby syndrome. He created, with assistance from his research and laboratory assistant Vivien Thomas and pediatric cardiologist Helen Taussig, the Blalock-Thomas-Taussig Shunt, a surgical procedure to relieve the cyanosis from Tetralogy of Fallot. This operation ushered in the modern era of cardiac surgery. He worked at both Vanderbilt University and Johns Hopkins University, where he studied both as an undergraduate and worked as chief of surgery. He is known as a medical pioneer who won various awards, including Albert Lasker Clinical Medical Research Award. Blalock was also nominated several times for the prestigious Nobel Prize in Medicine.

Mario Harvey (born August 10, 1987) is an American football linebacker who is currently a free agent. He was signed by the Pittsburgh Steelers as an undrafted free agent in 2011. He also played for the Indianapolis Colts and New York Jets, and played college football for Marshall University.

Robert Lanier Jackson (born February 16, 1940) is an American former football coach and college player who was a professional assistant coach in the National Football League (NFL) for 21 seasons, including three as an offensive coordinator. In his NFL tenure, Jackson coached five Pro Bowl running backs, including at least one in three of his five stops where he has tutored the running backs. The list consists of Pro Football Hall of Fame player Marshall Faulk (St. Louis Rams 2000–02), Stephen Davis (Washington Redskins 1999), Terry Allen (Washington Redskins 1996), Brian Mitchell (Washington Redskins, 1995), and Marion Butts (San Diego Chargers, 1990–91).

Alvin Toles (born March 23, 1963) is a former American football player who played linebacker for the New Orleans Saints in the National Football League from 1985 until 1988, when a knee injury ended his career. He played college football at the University of Tennessee, initially as a fullback before switching to linebacker his junior year. He was the Saints' 1st-round pick in the 1985 NFL Draft.

Eugene Talmadge (September 23, 1884 – December 21, 1946) was an American Democratic politician who served two terms as the 67th Governor of Georgia from 1933 to 1937, and a third term from 1941 to 1943. Elected to a fourth term in November 1946, he died before his inauguration, scheduled for January 1947. Only Talmadge and Joe Brown, in the mid-19th century, have been elected four times as Governor of Georgia. He is known for having actively promoted segregation and white supremacy, and for advocating for racism in the University System of Georgia.

Samuel Rutherford (March 15, 1870 – February 4, 1932) was an American politician, businessman, jurist and lawyer.

Edmund Dumas (February 15, 1810 – October 22, 1882) was an American Primitive Baptist minister, politician, and musician today remembered for his association with the Sacred Harp movement.

Jeff P. Iorg (born October 9, 1958) is an American author, pastor, church planter, teacher, speaker, and current president of Gateway Seminary (formerly Golden Gate Baptist Theological Seminary), an entity of the Southern Baptist Convention with five campuses located in the Western United States.

Harold Gravely Clarke (September 28, 1927 – February 26, 2013) was an American jurist and politician.